Abstract
POSTPARTUM THYROID DYSFUNCTION; CLINICAL VALUATION AND PROPHETIC INFLUENCE OF TPOAB AND PSYCHIATRIC AFFECTIVE ILLNESS

Moaaz Mohammed Nisar* and Mohammad Salman Muqtadir

ABSTRACT

Postpartum thyroid dysfunction (PPTD) occurs in 5-7 % of women, with hypothyroidism developing in 25 % of these after 3–6 yr. Authors have determined the prophetic implication of thyroid peroxidase antibody (TPOAb), human leukocyte antigen haplotype, and postpartum thyroid status on the development of thyroid dysfunction 77–81 months after PPTD. Thyroid dysfunction occurred in 46% of group 1 vs. 4% of group 2 (P, 0.001) and 24.5% of groups 1 and 2 vs. 1.4% of group 3 (P, 0.001). Factors predictive of thyroid dysfunction included a hypothyroid form of PPTD, TSH more than 20 mU/L, and higher TPOAb levels (213.8 kIU/L in group 1 vs. 131.8 kIU/L in group 2; P, 0.002) during the postpartum period. Although TPOAb was higher in group 1 than in group 2 at follow-up (166 vs. 97.7 kIU/L; P, 0.03), there was no significant fall in TPOAb levels within either group during the period of follow-up. Human leukocyte antigen DR10 was lower in those who developed late thyroid dysfunction. These data, representing the longest follow-up of PPTD women, clearly show that the hypothyroid form of PPTD and high TPOAb levels of long term thyroid dysfunction. This compares with a relative risk of 12.9 for TPOAb- and PPTD-positive women, who remained euthyroid at the end of the first postpartum year, and 2.8 for TPOAb-positive but PPTD-negative women, all compared to TPOAb-negative women.

Keywords: .


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tanima Debnath Sarkar

Download Article : Click here

News & Updation

  • EJBPS: DECEMBER ISSUE PUBLISHED

    DECEMBER 2021 Issue has been successfully launched on 1 December 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT