Abstract
FORMULATION OPTIMIZATION AND EVALUATION OF FAST DISINTEGRATING EFFERVESCENT TABLET OF PANTOPRAZOLE SODIUM

*Punam Shankar Patil, (M Pharm) and Dr. S. D. Barhate, (M Pharm, PhD)

ABSTRACT

The objective of this study was to formulate, optimize and evaluate fast disintegrating effervescent tablet of pantoprazole sodium by using the central composite design (CCD) to optimize the superdisintegrant concentration. The dosage forms were designed with incorporation of superdisintegrants i.e. crosscarmellose sodium and two effervescent agents i.e. citric acid, sodium bicarbonate to develop a dosage form which can accelerate drug disintegration and dissolution to enhance patient compliance. The dosage form was prepared by using direct compression method. The prepared fast disintegrating effervescent tablets were evaluated for pre-compression and post-compression parameters. FTIR studies indicated drug and excipients were compatible with each other. The optimized batch PS5 were passes all the pre-compression and post-compression parameters and it was given as best by the CCD. The disintegration time and % drug released was found to be 21 seconds and 98.57 % within 30 min respectively. It was concluded that fast disintegrating effervescent tablets of pantoprazole sodium were successfully prepared by direct compression method using crosscarmellose sodium and effervescent agents by using central composite design shows better results.

Keywords: Pantoprazole sodium, Crosscarmellose sodium, Citric acid, Sodium bicarbonate, Fast disintegrating effervescent tablets, Central composite design.


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