Abstract
FORMULATION, DEVELOPMENT AND EVALUATION OF POSACONAZOLE NANOEMULSION FOR OCULAR DELIVERY

Kiranbala Jain* and Meenakshi Bharkatiya

ABSTRACT

The aim of the present study was to formulate and evaluate the nanoemulsions of antifungal drug Posaconazole for its sustained and prolong effect. Pseudoternary phase diagrams were constructed, and various nanoemulsion formulations were prepared using Isopropyl myristate (IPM) as oil, Tween-80 as a surfactant and Transcutol P as a co-surfactant.A total of seven formulations was selected from the nanoemulsion region and all formulations were evaluated for the attribute such as viscosity, droplet size, pH, refractive index, surface tension, poly-dispersity index, zeta potential, osmolarity, drug content and in vitro drug release. The optimized nanoemulsion was subjected to TEM, ex vivo permeation, ocular irritancy, antifungal activity, sterility, in vivo studies and stability. The formulated nanoemulsions NE-1 to NE-7 showed acceptable physicochemical properties. NE-2 nanoemulsion was clear, transparent and elegant in appearance when compared to the other formulations. From primary evaluation, the NE-2 nanoemulsion was selected as optimized formulation because of higher zeta potential and drug content value and lower particle size as well as the poly-dispersity index. Posaconazole was effectively formulated in nanoemulsion form and can be a good candidate for ocular delivery as it holds high penetration through the cornea and good therapeutic efficacy for the treatment of fungal keratitis together with sustained effect.

Keywords: Ocular nanoemulsion, Microemulsion, Nanotechnology, Novel drug delivery system, Fungal keratitis, Keratomycosis.


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