European Journal of Biomedical and Pharmaceutical Sciences

A STUDY ON DRUG –DRUG INTERACTION INDUCED OUTCOMES IN ANTIBIOTIC COMBINATION THERAPY

Asna Hassan*, Parvathy K. J.*, Vivek P.*

ABSTRACT

Intensive care unit patients are particularly at a risk of developing infections with multi-drug resistant organism, which are more prevalent in this environment. Appropriate and adequate antibiotic is essential in the treatment of these patients. Antimicrobial combination therapy is a rational option with potential benefits in the patients who are at the risk of developing infections with multi-drug resistant organism. However, some antibiotic combinations exhibit antagonistic interaction that hinders treatment efficacy. Therefore, screening antibiotic combinations in terms of their interaction types prior to treatment is crucial.From the 100 prescriptions, 468 DDIs were identified. Based on severity, major (100) shows higher; based on MOA, Pharmacodynamic interactions (283) were more and Different variables such as age, gender, no. of drugs per prescription, and hospital stay associated with DDIs. MDR Klebsiella pneumonia were found major cause of multi drug resistant infection in patient. Prevalence of hospital acquired infection in 100 patients was 24%.

Keywords: Drug-Drug interactions, multidrug resistance, prevalence, antimicrobial combination therapy.