European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF TOPICAL HYDROGEL OF ANTIFUNGAL DRUG OF TERBINAFINE HCL (RESEARCH PAPER)

Vivek S. Harbade* and Nishan N. Bobade

ABSTRACT

Topical Hydrogel preparations are intended for skin application or to certain mucosal surfaces for local action or transdermal penetration of medicament or for their emollient or protective action. Terbinafine HCl is an antifungal drug use to treatment of fungal infection. The oral rout of drug is not recommended due to the side effect. Topical Preparation avoid the side effect associated due to oral formulation and give the local effect. This study was conducted to formulate and evaluate Terbinafine hydrochloride topical hydrogel for treatment of fungal infection of skin. The hydrogel was formulated by using different gelling agents like HPMC, Carbapol 934, Guar Gum and CMC in different concentration. The prepared hydrogel formulations were evaluated for physico-chemical parameters like physical appearance, pH, drug release, drug content. The in vitro drug release from Hydrogels was evaluated using Franz diffusion cell containing cellophane membrane with phosphate buffer pH 7.4 as the receptor medium. Drug-excipients compatibility studies were performed by FT-IR analysis. All Hydrogel formulations showed acceptable physico-chemical and rheological properties and results were found to be within the limits. The drug release was found to decrease with increase in polymer concentration. Among all the Hydrogel formulations HPMC and Guar Gum showed superior drug release than followed by Carbapol 934, CMC. Drug-excipients compatibility studies showed that there is no interaction between the drug and selected excipients.

Keywords: Terbinafine Hydrochloride, HPMC, CMC, Guar Gum, Carbapol 934, Franz diffusion, FTIR, Topical Hydrogel.