Abstract
EFFECT OF EXPOSURE TO SOOT ON TROPONIN I AND LIPID PROFILE LEVELS

Ihim Augustine C.*, Okeke Chizoba O., Manafa Patrick O., Ezejindu Damian N., Nnodim JohnKennedy, Obi Patrick C.

ABSTRACT

Exposure to soot, to some extent can lead to cardiovascular disease. This study was undertaken to determine serum Troponin I and lipid profile levels of cooks exposed to soot. 50 subjects (cooks) exposed to soot (test group) and 50 people not exposed to soot were recruited. Ethical approval was obtained from the Ethics committee of Faculty of Health Sciences and Technology, Nnamdi Azikiwe University and informed consents of the subjects were obtained. Troponin I was assayed using Enzyme-linked immunosorbent assay (ELISA). Total Cholesterol levels were determined using cholesterol enzymatic end-point method, Low density lipoprotein cholesterol (LDLC) levels were determined using clearance method while Spectrophotometric and Enzymatic Methods were employed for the High Density Lipoprotein Cholesterol (HDL-C) and Triglyceride while the BMI (Body mass index) was calculated using weight (kg)/height2 (m2). The results showed that the mean values of the serum troponin I level of cooks exposed to soot (test group) was significantly higher when compared with the control (4.29 ± 3.01) (P<0.05). The mean values of total cholesterol, LDL-C, Triglycerides and the BMI (10.29±3.37), (3.37±1.36), (1.43±0.52), (26.53±4.98) respectively were significantly higher in test group when compared with the control (8.92±6.11), (0.98±0.69), (0.95±0.51), (22.62±5.58) (p<0.05) while there was no significant decrease in HDL-C level in test group (2.74±0.68) when compared with the control (3.03±0.73) (p>0.05). This study showed an increased level of Troponin I, total cholesterol, Triglycerides, low density lipoprotein cholesterol and reduced level of High Density Lipoprotein among cooks exposed to soot, this suggests a predisposition to cardiovascular disorder.

Keywords: Soot, Lipid profile, Troponin I, Cardiovascular disease.


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