IN VITRO EVALUATION OF AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA L. ROOTS AGAINST ANTIBIOTIC RESISTANCE STREPTOCOCCUS MITIS ISOLATED BACTERIA FROM DENTAL CARIES PATIENTS IN MISSAN CITY.
*Mohammed A. Abd Ali
ABSTRACT
Twenty six isolates of Streptococcus mitis bacteria collected from clinical of dental disease in missan city, then
analyzed between (October and December in 2014). The samples taken in order to determine the bacterial profile
and antibiotic susceptibility. Isolates of Streptococcus mitis were tested against eight different antibiotics
and crude of aqueous extract from roots of Glycyrrhiza glabra L., by a disk diffusion method. 100% of
isolates were resistat to the Tetracycline, 84% resistant to Ampicillin, 96% resistant Nitrofurantion,
100% resistant to Optochin, 80% resistant to Bacitracin, 96% resistant to Erythromycin, 92% resistant to
Vincomycin, 73% resistant to Benzypenicillin where found to be the least effective antibiotics against Multidrug
resistance (MDR) Streptococcus mitis. Also the antimicrobial suscepitility of isolates where tested against
crude of crude aqueous extracts from root´s of Glycyrrhiza glabra L. with different concentration (62,5,125,
250,500mg/ml) detected by agar well diffusion methods, the aqueous extracts from roots of Glycyrrhiza
glabra L. have more effective in 500mg/ml. Finally cytotoxicity evaluating toward human RBC, the results
revealed these crud extracts Glycyrrhiza glabra L. have not any cytotoxicity in all concentration. The good
antimicrobial potency of crud extracts of Glycyrrhiza glabra L. indicates the treatment of MDR Streptococcus
mitis as an alternative to the costly antibiotics.
Keywords: Streptococcus mitis, Glycyrrhiza glabra L., Nitrofurantion.
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