European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF PIOGLITAZONE

P. Srikanth Reddy*, V. Alagarsamy, P. Subhash Chandra Bose, V. Sruthi and D. Saritha

ABSTRACT

At present, the most common form of delivery of drugs is the oral route. While this has the notable advantage of easy administration, it also has significant drawbacks namely poor bioavailability due to first pass metabolism and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and/or frequent dosing, which can be inconvenient.[1,2] To overcome these difficulties there is a need for the development of new drug delivery system; which will improve the therapeutic efficacy and safety of drugs by more precise (i.e., site specific), spatial and temporal placement with in the body thereby reducing both the size and number of doses. New drug delivery system are also essential for the delivery of novel, genetically engineered pharmaceuticals (i.e., peptides, proteins) to their site of action, without incurring significant immunogenicity or biological inactivation. Apart from these advantages the pharmaceutical companies recognize the possibility of re-patenting successful drugs by applying the concepts and techniques of controlled drug delivery system in bringing new drug to the market. One of the methods most often utilized has been transdermal delivery i.e., transport of therapeutic substances through the skin for systemic effect.[3-7] The present study was designed to develop a suitable matrix type transdermal drug delivery systems of Pioglitazone using different polymers HPMC E15, Eudragit L100 and to compare the drug release through physical method and chemical method.

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