European Journal of Biomedical and Pharmaceutical Sciences

PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES OF NIRGUNDI AND SACRED FIG FOR ANTIDIABETIC ACTIVITY

Ashok Kumar Yadav*, Ravi Prakash, Rahim Khan, Brajesh Kumar Arjariya and Vipul Sharma

ABSTRACT

For thousands of years the Indian traditional medicine, Ayurveda has been practiced in preventing and treating diseases and to maintain health. Some of these compounds may have therapeutic potential, while others may produce hypoglycemia as a side effect of their toxicity, especially hepatotoxicity. Several studies reported Nirgundi and Sacred fig used for treating various diseases and disorders. It is essential to investigate the properties of active phytocompounds. The solubility of the extract was higher in polar solvents like ethanol and water. It can be concluded from the above studies that nirgundi leaves possess potential bioactive compounds that have anti-inflammatory activity. Phytocompounds from the leaf of nirgundi plant can be used to discover bioactive phytodrugs that may serve as lead for development of a new antidiabetic drug. The significant antidiabetic and antioxidant activity indicates potential of this plant as a promising agent in the development of newer antidiabetic agent. It is also essential to identify and understand the molecular mechanism of its antidiabetogenic effect and to identify the bioactive compounds responsible for this effect. Our investigations confirmed the traditional use of this plant in the field of diabetes have clearly supported its use. These flavonoids are reported to possess good antidiabetic activity.

Keywords: Antidiabetic activity, Nirgundi, Sacred fig, Phytodrugs, Ayurveda.