European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL EVALUATION OF NOVEL HETEROCYCLIC PYRIDINE BASED THIOPHENE DERIVATIVE OF TRANSITION METAL COMPLEXES

Boya Rajannagari Chaitanya Kumar, Kondra Sudhakar Babu* and Palyam Shabana

ABSTRACT

The transition metal complexes (where [M = Co, Ni, and Cu]) with pyridine based thiophene derivative of 2-((E)-2-((5-bromothiophen-2-yl) methylene)hydrazinyl)-4-methyl-6-phenylpyridine-3-carbonitrile [BTHPC] ligand has been devised and synthesized. The physico-chemical, analytical data, UV-Vis, FT-IR, 1H-NMR, and ESR spectrum methods were used to characterize all the complexes. Ligand and Metal complexes were screened for cytotoxicity on lung cancer cell lines and hepatic cancer cell lines A549 and HepG2 respectively, with MTT assay. Antibacterial studies were done against different pathogens of gram positive and negative bacteria. Copper complex has more significant cytotoxicity and antibacterial activity than Nickel and Cobalt complexes.

Keywords: Pyridine-thiophene derivative, Transition metals, cytotoxicity studies, MTT assay, Antibacterial activity.