Abstract
FORMULATION AND PROCESS VALIDATION OF LOSARTAN POTASSIUM FLOATING TABLETS FOR GASTRIC RETENTION IMPROVEMENT

Sriranga T.*, Sreenivasa G. M., Naveen S. Banakar, S. A. Sidlingajja, Shapiulla P. and Vaishakha Kori

ABSTRACT

The objective of the present study was to formulate and validate losartan potassium as single unit floating tablets in order to improve its bioavailability. losartan potassium was chosen as a model drug because of its low bioavailability and shorter half-life. Losartan potassium floating tablets were prepared by wet granulation technique using different concentrations of hydroxy propyl methyl cellulose (HPMC) and sodium alginate as gelling polymers with other excipients, Sodium bicarbonate was used as gas forming agent. The formulations were optimized on the basis of in-vitro buoyancy and dissolution in simulated gastric fluids of 0.1 N HCL.

Keywords: Losartan potassium, HPMC, Sodium alginate, Flotaing drug delivery system.


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