Abstract
PHYTOCHEMICAL INVESTIGATION AND IN-VITRO ANTHELMINTIC ACTIVITY OF PONGAMIA PINNATA

Praveen Kumar Dasari*, Yadamakanti Sandhya Rani, Maddela Nikhil, Ummadi Bhavani, Guduru Sai Krishna, Tanuku Satyanarayana

ABSTRACT

Many herbal extractions individual or combination have been recommended in various medical values for the cure of different diseases. The present research work deals with phytochemical investigation and anthelmintic activity of Pongamia pinnata bark. Standardization of crude drug extracted from plants play an important role in identifying the quality and purity of drugs. Phytochemical constituents are extracted by petroleum ether, acetone, chloroform and ethanol from Pongamia pinnata belongs to the family Fabaceae. This research gave information that ethanolic extracts of Pongamia pinnata bark had the highest number of phytochemicals compared to other solvent extracts. Hence, ethanolic extracts of Pongamia pinnata holds the greatest potential to treat various human diseases and has profound medical applicability. In-vitro anthelmintic activity was determined by taking adult Indian earthworms, Pheretima posthuma having anatomical and physiological resemblance with intestinal roundworms. These earthworms were washed in normal saline solution before they were used. To observe anthelmintic activity, all the investigations were carried out by ethanolic extract with different concentrations of 10, 25, 50mg/ml, significant activity like time of paralysis and time of death were reported. At highest concentrations of 50mg/ml, a significant anthelmintic activity was observed and compared with piperazine citrate as standard reference with difference concentrations 10, 25, 50mg/ml and distilled water as control. Herbal drugs and synthetic drugs were equally effective in helminthic infestations but ethanolic extract of Pongamia pinnata bark exhibits potentiality and have maximum anthelmintic activity.

Keywords: Pongamia pinnata bark, Phytochemical investigation, Piperazine citrate, Pheretima posthuma.


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