European Journal of Biomedical and Pharmaceutical Sciences

PHARMACOLOGICAL ACTIVITY OF JASMINUM GRANDIFLORUM LEAVES FOR THE MANAGEMENT OF TYPE 2 DIABETES

Rahim Khan*, Har Govind Garg, Mohd. Jalauddin, Sheenam Mansuri and Ashok Kumar Yadav

ABSTRACT

Type 2 diabetes mellitus (DM) is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world. As a result of this trend, it is fast becoming an epidemic in some countries of the world with the number of people affected expected to double in the next decade due to increase in ageing population, thereby adding to the already existing burden for healthcare providers, especially in poorly developed countries. Jasminum grandiflorum also known as Spanish Jasmine is a night bloomy flowering plant and is an important source of methyl jasmonates which find utility in plant defense, fruit ripening, plant growth senescence and other physical processes. Jasminum grandiflorum has diuretic and emmenagogue properties. The fresh juice of leaves is applied to corns, and the leaves are chewed and used in the treatment of ulcerations of the mouth. The leaves contain resin, salicylic acid, and an alkaloid named jasmine. The aim of the present study was to evaluate the pharmacology activity of leaves of Jasminum grandiflorum collected from Bhopal region of Madhya Pradesh. Preliminary phytochemical screening of the leaf Jasminum grandiflorum extract showed the presence of alkaloids, Flavonoid, terpenoids, tannins, phenolic compounds and saponins. The significant ant diabetic, antihyperlipidemic, and antioxidant activity of the leaf of Jasminum grandiflorum in this study may be attributed to the presence of these principal constituents. The results conclude that the methanol extract of Jasminum grandiflorum has potential anti-diabetic action in STZ induced diabetic rats and the effect was found to be more similar to the reference drug glibenclamide.

Keywords: Jasminum grandiflorum, Diabetes mellitus, streptozotocin, Glibenclamide, phytochemical analysis.