European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF THYMOQUINONE AND CAMEL MILK ON LIVER FUNCTION OF STREPTOZOTOCIN INDUCED DIABETIC ALBINO RATS

Adel Abdel Moneim*, Hamdi Helmy, Eman S. Abdel-Reheim and Wsam Addaleel

ABSTRACT

The present study was designed to evaluate the beneficial hepatoprotective effects of thymoquinone (TQ) and camel milk (CM) on streptozotocin induced diabetic albino rats by assaying liver function enzymes (ALT&AST) and serum protein profile in both prophylactic and treated groups. The serum AST showing a significant decrease in its activity in all groups after treatment ,while CM in prophylactic group has the most significant effect followed by TQ in treated group. However, TQ in treated group exhibited the most significant effect on ALT activity along with the same significant decrease in the other groups. Given that the high protein content of camel milk, total proteins and globulin in both CM prophylactic and treated groups were significantly improved more than TQ prophylactic and treated groups. Otherwise, albumin concentration improved significantly in all tested groups. Moreover, highly significant improvement in A/G ratio of both TQ prophylactic and treated groups more than those of CM prophylactic and treated groups. In conclusion, administration of both thymoquinone and camel milk exhibited ameliorative and hepatoprotective beneficial effects on diabetic albino rats.

Keywords: Thymoquinone, camel milk, hepatoprotective, prophylactic, treated groups.