INTERACTION OF CAFFIENE WITH EXOGENOUS OXYTOCIN ON LIMBIC SEXUAL BEHAVIOURAL ORIENTATION IN WISTAR ALBINO RATS
Olorunfemi Oluwadare Joyce*, Solomon Uvoh Micah, Kiridi Emily Gabriel, Ngaikedi Charles Nnamdi, Inwang Uduak Anthony and Bohr Edward Lete
ABSTRACT
Aim/background: Study of the Interaction of caffeine with exogenous oxytocin on limbic sexual behavioral orientations in wistar albino rats was carried out. Method: 30 male and female albino rats were divided into four study groups. Group 1 was treated with caffeine only, group 2 was treated with oxytocin and caffeine simultaneously, group 3 was treated oxytocin only and while group 4 was used as drug-free control. The 4-week study employed various standard sexual orientation behavioral observations and tests to study the direct influence of drug and drug-drug interaction on sexual activities in these categories; general sexual behaviors, (i.e. mounting frequency & latency, intromission frequency & latency), male sexual orientations towards female, (i.e. sniffing & licking, genital and non-genital grooming, raring & climbing), female sexual orientations towards male (i.e. solicitation, ear wriggling, lordosis, allowing mounting). Results: The observations and results revealed significant and marked improved sexual behavior in the group 3, treated with oxytocin and caffeine compared with those treated singly with either oxytocin or caffeine only. Conclusion: The synergy could suggest enhanced sexual performance both in the male and female and may prove to be useful in sex-related improvement regimen.
Keywords: caffeine, oxytocin, sexual behavior, wistar rat, sexual orientation.
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