Abstract
FORMULATION AND CHARACTERIZATION OF ORAL THIN FILM CONTAINING DOMPERIDONE HYDROCHLORIDE

Sheenam Mansuri*, Rahim Khan, Dr. Mohd Jalaluddin, Rajkumar Sharma and Md. Mazhar Mansuri

ABSTRACT

The aim of the present work was to formulate and characterise oral thin film containing domperidone hydrochloride. To prepare the film, Maltodextrin, Hydroxy propyl methyl cellulose E3LV, Hydroxy propyl methyl cellulose E5LV and Hydroxy propyl methyl cellulose E15LV were used as film-forming polymers by solvent casting method. Propylene Glycol and Glycerine was used as plasticizer, aspartame, and mannitol as sweetener. All prepared films were evaluated for its weight variation, disintegration time, thickness, drug content, pH, dissolution study, and folding endurance. The drug-excipients compatibility study was done using differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR). Satisfactory results obtained when Hydroxy propyl methyl cellulose E5LV was used as film-forming polymer, and the drug was dispersed in the polymer solution using poloxamer 407 as a solubilizing agent. DSC and FTIR studies showed no interaction between drug and the polymers. It can be concluded from the study that the fast-dissolving film can be prepared for poorly water-soluble drug domperidone hydrochloride using Hydroxy propyl methyl cellulose E5LV as a suitable film-forming polymer.

Keywords: Domperidone hydrochloride, Fast dissolving film, Hydroxypropyl methylcellulose E5, Solvent casting method.


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