European Journal of Biomedical and Pharmaceutical Sciences

QSAR: A USEFUL TOOL FOR DESIGNING NEW DRUG AND PREDICTING THEIR BIOLOGICAL ACTIVITIES

*Dr. Subhashini Sharma

ABSTRACT

It has been seen that discovery of a new drug is such a challenging process that out of hundreds compounds synthesized in research laboratories only one or sometimes none reaches the market ultimate as a' drug'. It has been estimated that traditional process of synthesis of compounds is based on trial and error method and random screening of the compound to test its activity is very expensive and time consuming. The recent advanced technologies in the field of pure and applied science, analytical chemistry and computer science have proved to be useful tools for designing new chemicals and predicting their biological activities before synthesis. QSAR is a quantitative structure activity relationship by which a chemist is enabled to describe and elucidate the effect of various physiochemical properties on drug potency and to determine biological activities of new compounds.

Keywords: QSAR, new drug, biological activity, physiochemical properties, elucidation.