European Journal of Biomedical and Pharmaceutical Sciences

PREPARATION AND EVALUATION OF RAPIDLY DISSOLVING TABLETS OF CARVEDILOL

Aliaa Mohammed Nagib Elgendy*, Esmat E Zein and Gamal M. El Maghraby

ABSTRACT

The aim of this work was to fasten the rate of dissolution of carvedilol via controlled precipitation, in presence or absence of hydrophilic polymers. The goal was to develop rapidly disintegrating tablets with fast dissolution of carvedilol. Aerosil was dispersed in methanolic solution of carvedilol in the presence or absence of hydrophilic polymers. Distilled water was added as antisolvent to produce controlled precipitation. The precipitate was centrifuged and dried at ambient conditions before monitoring the dissolution pattern. The properties of solid products were investigated using FTIR spectroscopy, thermal analysis and X-ray diffraction. FTIR studies revealed significant alteration in spectrum of carvedilol after controlled precipitation. These changes can be taken as possible indicators for hydrogen bonding. The thermal analysis reflected possible co-crystallization between carvedilol and aerosil and in presence of hydrophilic polymers. This was further confirmed by X-ray diffraction. Changes recorded in crystalline nature of carvedilol were associated with enhancement in dissolution rate of carvedilol. Optimum formulations were formulated as rapidly disintegrating tablets with subsequent fast dissolution. In conclusion, optimized sedimentation of carvedilol via controlled precipitation technique in presence of aerosil and different hydrophilic polymers resulted in development in co-crystal development which enhance dissolution rate of carvedilol.

Keywords: Carvedilol, controlled precipitation, enhance dissolution, fast disintegrating tablets.