European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF HYDROPHOBIC POLYMER BASED MATRIX SUSTAINED RELEASE TABLETS OF CAPTOPRIL

*Shreyash Mishra and Prof. (Dr.) Pranav Kumar Upadhyay

ABSTRACT

The purpose of the present study was to prepare oral sustained release matrix tablets of highly water soluble drug, Captopril using a hydrophobic polymer compritol (glyceryl behenate) and to evaluate the effect of hydrophobic polymer and effect of methods of preparation on the release of the drug The tablets were prepared by direct compression, wet granulation techniques. The matrix tablets were evaluated for various parameters as physical appearance, dimensions, hardness, weight variation, friability, drug content, in vitro dissolution studies. Also the matrix tablets prepared by hot melt granulation showed more effective retarded release rate than tablets prepared by direct compression and wet granulation techniques. Compritol 888 ATO can be used as a matrix former to sustain the release of water soluble drugs. Tizanidine hydrochloride tablets were prepared by melt direct compression technique using xanthum gum, glyceryl behenate, glyceryl monostearate and stearic acid in different proportion. Formulated sustend release tablets were evaluated for appearance, dimensions (diameter and thickness), weight varation, hardness, friability, drug content and in-vitro release of Tizanidine hydrochloride.

Keywords: Oral sustained release matrix tablets, Tizanidine hydrochloride, Hydrophobic polymer compritol, Matrix tablets, Compritol 888 ATO, Glyceryl behenate.