AUGMENTATION OF DISSOLUTION PROFILE OF POORLY SOLUBLE OLMESARTAN MEDOXIMIL FORMULATING INTO PRONISOMES
N. Shyam Prasad*, Swapna S., Dr. Madhu Babu A. and Dr. Vasudha Bakshi
ABSTRACT
The present study was designed to investigate the possibility of manufacturing proniosomes and using
proniosome-based niosomes as drug carriers. The results reported here indicate that Proniosomes are very
promising as drug carriers. The present formulation study on Olmesartan medoximil is an attempt to prepare
proniosome based niosomal drug delivery system by slurry method using spray dried lactose as carrier and to
evaluate its performance. The proniosomes with various types and contents of nonionic surfactant and cholesterol
is evaluated in this study. The proniosome formulation was evaluated for FT-IR study, angle of repose and
scanning electron microscopy. The niosomal suspensions were further evaluated for entrapment efficiency, Invitro
release study, Kinetic data analysis, Stability study. The result from SEM analyses has showed porous
surface of proniosome. The formulation F9 which showed higher entrapment efficiency of 85.23 ± 1.34 and invitro
releases of 97.63 ± 0.24% at the end of 13 hr was found to be best among the all 12 formulation. Release was
best explained by the first order kinetics. Correlation value of Higuchi’s plot revealed that the mechanism of drug
release was diffusion. The in vitro kinetic data subjected to log time vs log drug release transformation plot
(peppa’s model), the value lies were found to be n<0.5 this revealed that the drug release follows a fickian
diffusion. Proniosome formulation has showed appropriate stability for 90 days by storing the formulation at
accelerated stability condition.
Keywords: Olmesartan medoximil, proniosomal powder, spray dried lactose.
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