European Journal of Biomedical and Pharmaceutical Sciences

EXPLORING THE IMPACT OF ANAEMIA, QUALITY OF LIFE AND SLEEP DISTRUBENCES IN NON-HEMODIALYSIS AND HEMODIALYSISPATIENTS DOCTOR OF PHARMACY

M. Priyanka*, N. Meghana, P. Nehasai, P. Snigdha and Dr. R. Dinesh

ABSTRACT

Introduction: Chronic kidney disease (CKD), also known as chronic renal insufficiency or progressive kidney disease could be a condition within which kidney function gradually deteriorates over time. Kidney function impairment, defined as a glomerular filtration rate (GFR) of less than 60 ml/min/1.73m2 on a minimum of two times over three months. Anemia, a decrease in the hemoglobin (Hb) carried within red blood cells, is a common complication of CKD and is associated with debilitating symptoms, including fatigue, weakness, shortness of breath, dizziness, headaches and depression. Anemia has been defined as Hb < 12 g/dL in women and < 13 g/dL in men. Sleep is a biological necessity for maintaining mental and physical well-being. It is a state of diminished physical activity and limited consciousness in which the organism slows down and restores itself. Health-related quality of life (HRQOL) is known to be reduced in patients with CKD, and the presence of anemia appears to be associated with exacerbation of HRQOL impairment. Methodology: It is a prospective and cross-sectional study conducted in In-patient and Outpatient department for 6months. Among 105 subjects who met inclusion criteria were evaluated and monitored. Statistical procedure of Pearson’s correlation coefficient, Anova, Chi square test and t-test was done in Excel sheet. Results: In the data of anemia greater number of patients was found at the age of 51-60 (43.8%). The median age of the patients found to be 55.5 years. In those patients about 66.66% are on iron supplementation. Comorbidities like hypertension (69.5%), diabetes (41.90%). Of all the patients male patients were greater (75.23%) compared to that of females (24.7%). In the data of sleep, 68 patients were taken as poor sleepers (64.76%) and 37 patients were taken as good sleepers (35.23%) which includes both HD and Non-HD patients. Gender wise calculated and found sleep disturbances in males72.38% and females 27.61%. Greater number of patients was found in 50-59 (30.47%). In quality of life, there a negative impact found between progression of CKD and HRQOL. Conclusion: In the conclusion, Anemia is the first known systemically reviewed complication in the progression of the disease. Appropriate treatment that not only manages anemia but also reduces the negative outcomes, that may reduce burden of anemia. Many sleep disturbances are seen but at present no treatment is specified, as of now. Sleep disturbances are referred as to one of the most important distressing symptoms which affect QOL and the mortality risk. In early stages, QOL decreases but latter it shows negative impact with progression of disease.

Keywords: Anemia, Quality of life, Sleep disturbances, Non-Hemodialysis, Hemodialysis.