Abstract
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NEWER QUINAZOLINE BASED DERIVATIVES

Subodh Kumar*, Vivek Thakur, Deepak Basedia and Balkrishna Dubey

ABSTRACT

In the present work newer antibacterial agents based on Quinalzoline scaffold were synthesized and evaluated. The synthesized compounds were characterized for the physicochemical properties such as melting point, colour and solubility. All the compounds were yellowish to brown in colour and were obtained in 57-67% yields using the optimized reaction conditions. The compounds were insoluble in water, slightly soluble in methanol, soluble in chloroform and DMSO. Antibacterial activity of the synthesized compounds against four tested microorganisms was determined. The zone of inhibition was obtained as the primary indicator of the antibacterial action and the MIC value of the compounds was established using serial dilution technique. The antibacterial activity of QZSB 4 was the maximum of all the compounds. On the other hand, QZSB 1 and QZSB 5 exhibited the least zone of inhibitions and the highest MIC values.

Keywords: Quinalzoline, antibacterial, zone of inhibition, MIC, serial dilution.


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