Tirupati M. Rasala*, Dr. Rajesh Mujariya, Shubham N. Kalbande, Prachi Pahade and
Dr. Abhay M. Ittadwar


The primary idea of QBD is “The Quality cannot be examined into the product; however it must be constructed into it.” Quality through design is the cutting-edge technique for the true standard of pharmaceuticals. It describes use of Quality through design to make certain grade quality of Pharmaceuticals. In this review paper, the Quality through design and a number of its parameters are described. This review article involves the benefits of QBD, steps involved in the QBD process and the applications of QBD. The compiled data from various research articles explains the importance as well as future need of QBD parameters. QBD plays a major role in screening of various formulated product, it is not only saving the time but it is proven beneficial for the economy of various manufacturing companies. Now a days emerging pharmaceutical companies are developing their interest towards QBD studies to depict factors interfering in the results. QBD makes it easier to achieve the best suitable batch in pharmaceuticals. QBD has its own contribution to the drug layout, improvement, and manufacture of extraordinary drug merchandise. It is better to know the quality target product profile (QTPP) for identification of critical quality attributes (CQA). This article will be beneficial in predicting CQAs, CMA etc. QBD involves the application of different design tools such as Plackette Burman, Boxe-Behnken, Central Composite, RSM etc. Hence Quality through design is totally a novel technique for making advancement in the field of medicine, which may be stated as a remedy with pharmaceutical advances.

Keywords: Pellets, FMEA, Ishikawa Plot, CQA, ANOVA.

[Full Text Article]


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