European Journal of Biomedical and Pharmaceutical Sciences

PREPARATION AND EVALUATION OF CONTROLLED RELEASE OF CARVEDILOL

B. Premkumar* and T. Shiva Sai

ABSTRACT

The aim of present investigation is preparation, characterization and evaluation of oral controlled release matrix tablets of Carvedilol in order to improve efficacy and to reduce the side effects. Tablets were prepared by direct compression method using different polymers like Ethyl Cellulose, HPMC K100M, Sodium Alginate and Chitosan. The tablets were evaluated for pre-formulation characteristics, post compression parameters, drug content and in-vitro dissolution release studies. In-vitro dissolution studies were carried out for 8 hrs and the results showed that among the nine formulations F5 showed good dissolution profile to control the drug release respectively. The stability studies were carried out according to ICH guideline which indicates that the selected formulation F5 was stable. In conclusion the results suggest that the developed matrix tablets of Carvedilol could perform therapeutically better than conventional dosage form, leading to improved efficacy and better patient compliance.

Keywords: Carvedilol, polymers, direct compression technique, in vitro drug release studies, stability studies.