European Journal of Biomedical and Pharmaceutical Sciences

A CASE REPORT ON SERUM CORTISOL INDUCED SIADH ASSOCIATED WITH SEVERE HYPONATREMIA

Dr. Mohammed Muneeruddin*, Poojitha Mutte, Divya Amara, Tejaswi Uppala and Dr. Venu Talla

ABSTRACT

Cortisol production is reduced in primary adrenal insufficiency. Electrolyte imbalance develops in patients, which can be severe and life-threatening. We discuss the example of a 55-year-old male who was taken to the hospital with chief complaints of vomiting since20 days. On evaluation the test results revealed chronic hyponatremia. The underlying reason was discovered to be primary adrenal insufficiency after further investigation. Our case study demonstrates that extreme hyponatremia can appear with neurological signs and symptoms. In the case of this patient, correction of hyponatremia, treatment with Tab. tolvaptan (Selective, competitive vasopressin receptor- 2 antagonist), Inj. ondansetron (Anti-emetic) and water restriction resulted in full clinical recovery.

Keywords: Adrenal insufficiency, Cortisol, Hyponatremia,SIADH (Syndrome of inappropriate antidiuretic hormone secretion).