European Journal of Biomedical and Pharmaceutical Sciences

GREEN SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF IMIDAZOLE DERIVATIVES

Priya Verma, Deepak Basedia, Vivek Thakur, Balkrishna Dubey and Brijeshkunvar Mishra*

ABSTRACT

The objective of the present investigation was to synthesize imidazole derivatives using microwave irradiation and evaluating them for antibacterial action. The synthesis was accomplished in two steps. While the first step was performed by conventional method, the second step that involved a modification of the triphenyl imidazole was performed using microwave irradiation for 30 to 120 seconds at 100 W power. The FTIR spectra of all the compounds exhibited stretching and bending vibrations for CH, C=N, C-N whereas N-O, C-O, C-Cl and C-Br stretching peaks were prominent in the corresponding compounds. The antibacterial activity of the synthesized compounds was determined using zone of inhibition method against gram positive (S. aureus, B. subtilis) and gram negative bacteria (E. coli, Salmonella). The presence of electron withdrawing groups in the compounds favored antibacterial activity against gram negative bacteria (5b, 5d & 5e) whereas electron donating group favored activity against gram positive bacteria (5b). Compound 5a did not exhibit significant antibacterial action as compared to the control (DMF).

Keywords: Imidazole, microwave, antibacterial, FTIR, spectra.