Abstract
GREEN SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF IMIDAZOLE DERIVATIVES

Priya Verma, Deepak Basedia, Vivek Thakur, Balkrishna Dubey and Brijeshkunvar Mishra*

ABSTRACT

The objective of the present investigation was to synthesize imidazole derivatives using microwave irradiation and evaluating them for antibacterial action. The synthesis was accomplished in two steps. While the first step was performed by conventional method, the second step that involved a modification of the triphenyl imidazole was performed using microwave irradiation for 30 to 120 seconds at 100 W power. The FTIR spectra of all the compounds exhibited stretching and bending vibrations for CH, C=N, C-N whereas N-O, C-O, C-Cl and C-Br stretching peaks were prominent in the corresponding compounds. The antibacterial activity of the synthesized compounds was determined using zone of inhibition method against gram positive (S. aureus, B. subtilis) and gram negative bacteria (E. coli, Salmonella). The presence of electron withdrawing groups in the compounds favored antibacterial activity against gram negative bacteria (5b, 5d & 5e) whereas electron donating group favored activity against gram positive bacteria (5b). Compound 5a did not exhibit significant antibacterial action as compared to the control (DMF).

Keywords: Imidazole, microwave, antibacterial, FTIR, spectra.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: NOVEMBER ISSUE PUBLISHED

    NOVEMBER 2022 Issue has been successfully launched on 1 NOVEMBER 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT