European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION DEVELOPMENT AND EVALUATION OF NANOPARTICLES OF VALSARTAN BY EMULSIFICATION METHOD

Ulsa Chandra Babu, V Jhansi Priya Marabathuni and Naidu Narapusetty*

ABSTRACT

Valsartan is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. As biological half life of drug is 15.6 hrs and belongs to BCS class II. To overcome with these problems, Nanoparticles of Valsartan were formulated by using Ethyl Cellulose, Eudragit RS 100 & Eudragit Rl 100 as a polymer by emulsification method. Among all the 9 formulations F6 formulation is optimized, as it shows maximum drug release at the end of 12hrs which suits the controlled release drug delivery system criteria as per our studies, having acceptable particle size, SEM and Zeta potential value. From the drug release kinetics of F8 formulation of Valsartan Nanoparticles dispersion it was concluded that the F8 formulation follows Zero order drug release with super case II transport mechanism.

Keywords: Valsartan, Nanoparticles, particle size, SEM and Zeta potential.