EFFECT OF AQUEOUS LEAF EXTRACT OF LAWSONIA INERMIS ON LEAD ACETATE-INDUCED LIVER IMPAIRMENT IN WISTAR RATS
Edobor Obayuwana* and Endurance Osakioduwa Imafidon
ABSTRACT
Background: Lead is one of the most hazardous and persistent metal in the world. It has been implicated in several conditions. Lawsonia inermis, on the other hand, has been reported to possess hepatoprotective activity, amongst others. The goal of this study was to investigate the effect of aqueous leaf extract of Lawsonia inermis on lead acetate-induced liver impairment in Wistar rats. Methods: Thirty-five Wistar rats weighing between 167 and 204 grams were obtained from the University of Benin's Department of Anatomy in Benin City, and divided into seven groups of five animals each. Group A, B, C, D, E, F and G received distilled water (2 ml), 400 mg/kg aqueous extract of L. inermis only, 100 mg/kg of lead acetate only, 100 mg/kg of lead acetate and 70 mg/kg of Silymarin, 100 mg/kg of lead acetate and 200 mg/kg of L. inermis, 100 mg/kg of Lead acetate and 400 mg/kg of L. inermis, and 400 mg/kg of L. inermis and 100 mg/kg of Lead acetate, respectively. After treatment, blood and liver tissues were collected for analysis. Results: The administration of L. inermis extract protected the plasma membrane from lead acetate, and also increased the liver's regenerative and reparative capacity, as evidenced by significant reductions in serum ALT, AST, ALP, and total bilirubin levels, in addition to results from the histopathological analysis. Conclusion: The hepatoprotective and ameliorative activity of Lawsonia inermis aqueous leaf extract against lead acetate-induced liver damage in Wistar rats was clearly observed as a result of this investigation.
Keywords: Liver, L. inermis, lead acetate, hepatotoxicity, Wistar rats.
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