European Journal of Biomedical and Pharmaceutical Sciences

EXPERIMENTAL OSTEOPOROSIS: DIFFERENT METHODS AND SPECIAL EMPHASIS ON GLUCOCORTICOID-INDUCED OSTEOPOROSIS

Dalia A. Elbahy*, Mahmoud H. Abd El Reheem, Sanaa A. Ahmed

ABSTRACT

Osteoporosis (OP) is the most common systemic skeletal disease characterized by progressive bone loss and increase fragility fractures, it affects commonly the old population and females more than males. It's a worldwide challenge as OP affects more than 200 million people, in addition, it impacts a great economic burden in the aging population due to increased dependence and mortality. Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary OP, that was observed with their prolonged use in the treatment of autoimmune disease, neoplasms, and organ transplantation. Designing a proper experimental model of OP is necessary to understand the pathological mechanisms and to evaluate the efficacy of new drugs. There are different methods for induction of experimental OP including: pharmacological, surgical, immobilization, diet, and transgenic. Also, combinations of these methods have the advantage of reducing the time needed for induction of OP and ensuring an apparent OP model.

Keywords: .