European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON OSMOTIC DRUG DELIVERY SYSTEM

Pallavi Sonkar* and Vivek Kumar Patel

ABSTRACT

Conventional drug has little control over their drug release and almost no control over the effective concentration at the target site. This type of dosing pattern may result in fluctuation in plasma concentration. Hence to avoid the shut comings there is development of various osmotic drug delivery system (ODDS). The ODDS utilizes the basic principle of osmotic pressure for controlled release of drug and it delivers drug in optimized manner to maintain drug concentration within their therapeutic window & minimize side effect. The release of drug from osmotic system depends upon various formulation factor such as solubility, osmotic pressure of core components, size of delivery orifice and nature of rate controlling membrane. This review paper highlights the theoretical concepts of drug delivery, principle and types of osmotic drug delivery system with basic component has been discussed briefly.

Keywords: Osmosis, Osmotic Drug Delivery System, Osmotic Pressure, Controlled Formulation, Osmotic Pump.