A REVIEW OF MICROEMULSIONS AS EXCELLENT CANDIDATES FOR OCULAR DRUG DELIVERY SYSTEM
Sourabh Dixit*, Dr. Rajesh Kumar Nema, Madhu Sahu, Aysha Quraishi, Subrata Paul, Preetam Mandal, Sarika Sahu
ABSTRACT
Ocular drug delivery has remained as one of the most challenging task for pharmaceutical scientists. The unique structure of the eye restricts the entry of drug molecules at the required site of action. Targeted drug delivery has generated a great deal of interest in the field because of its potential to overcome many barriers associated with current therapy many newer carriers are evolving with the advent of technology and the demand of targeted delivery like microemulsions. Microemulsions are an attractive technology platform for the pharmaceutical formulator as they are thermodynamically stable, possess excellent solubilization properties, and their formulation is a relatively straightforward process. They can be used to optimize drug targeting without a concomitant increase in systemic absorption. The role of microemulsion in providing novel solutions to overcome the problems of poor aqueous solubility of highly lipophilic drug compounds and provide high, more consistent and reproducible bioavailability. Current momentum in the invention of new drug delivery systems hold a promise towards much improved therapies for the treatment of vision threatening disorders. Previous research works showed higher percentage of surfactant used for the formation of microemulsions, irrespective of different routes of administration, but there is a lack of toxicological evaluation of the prepared microemulsions, which can be a broad research area in future.[1]
Keywords: ocular drug delivery, microemulsion, thermodynamically stable, toxicological evaluations.
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