Abstract
A REVIEW ON THE ESTIMATION OF LENALIDOMIDE IN DIFFERENT MATRICES

Sindhuja S., Tharagesh K., Vijayageetha R.*, Bharani pandilla, Sakthimaan Singh B. and Sathiyasree G.

ABSTRACT

Due to the clinical importance of lenalidomide in multiple myeloma, a large number of analytical procedures have been devised to detect the presence of this drug in pharmaceutical samples. In this manuscript, a review on the various techniques described to determine lenalidomide is presented. Special attention has been paid to spectrophotometric and chromatographic techniques, but also to relevant methods using fluorimetry, capillary electrophoresis as well as the detection modes coupled to these techniques. The review also focuses on the different degradation pathways of the drug and methods to identify and quantify it.

Keywords: Lenalidomide, Multiple myeloma, Ultraviolet spectroscopy, Liquid Chromatography, Fluorimetry, Capillary electrophoresis.


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