Abstract
FORMULATION AND EVALUATION OF A HYDRODYNAMICALLY BALANCED GASTRORETENTIVE DRUG DELIVERY SYSTEM INCORPORATING CIPROFLOXACIN HYDROCHLORIDE

Gautam D. Mehetre*, Pavan P. Chinchole, Mahesh B. Narkhede

ABSTRACT

Drugs that have narrow absorption window in the gastrointestinal tract (GIT) will have poor absorption. For these drugs, gastroretentive drug delivery systems offer the advantage in prolonging the gastric emptying time. The present investigation concerns the development of hydrodynamically balanced tablets of Ciprofloxacin Hydrochloride, are designed to prolong the gastric residence time after oral administration and thereby increasing drug bioavailability. Floating tablets of Ciprofloxacin HCl were prepared by direct compression using HPMC K4M and HPMC K15M as polymers along with Sodium bicarbonate as gas generating agent. The tablets were evaluated for in- vitro buoyancy, dissolution studies and physical characteristic viz.Density, Hardness, Friability, Thickness and Weight variation. Further, tablets were evaluated for in-vitro release characteristic for 12 hrs. It is found that the hardness of the tablets affects the Buoyancy characteristic of the dosage form. All formulations possessed good floating properties with total floating time more than 12 hrs. The in-vitro release studies indicated that the floating tablets of Ciprofloxacin HCl containing 200mg HPMC K15M (F4) showed sustained release when compared with the other formulation batches and provides a better option for controlled release action and improved bioavailability.

Keywords: Ciprofloxacin hydrochloride, gastroretentive, HPMC, in vitro studies.


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