Abstract
COCRYSTALS OF RAMIPRIL FOR ENHANCEMENT OF SOLUBILITY AND DISSOLUTION PROPERTIES

Radhika Kotame*, Gayatri Wagh and Ehtesham Ansari

ABSTRACT

This research work was intended to improve the solubility and dissolution properties of Ramipril by the develop ment of bicomponent cocrystals. Bicomponent cocrystals of Ramipril were prepared with β-cyclodextrine cocrystal former (CCF) by neat grinding techniques. Solubility analysis of cocrystals showed that Ramipril cocrystals have comparatively better solubility than the other cocrystals. The solubility of pure Ramipril (257.23 μg/mL) was found to be improved by seven folds (1799.61 μg/mL) due to the formation of bicomponent crystalline form with β-cyclodextrine. In vitro dissolution also revealed that the immediate release tablet of Ramipril showed a release of 59.60±1.31%, while Ramipril cocrystal tablet showed drug release of 95.65±1.21 % after 60 minutes. Results of Differential Scanning Colorimetry (DSC), Powdered X-Ray Diffraction (PXRD) and Raman spectroscopic analysis also justified the formation of the novel crystalline form. The developed bicomponent cocrystals of Ramipril improved the solubility and dissolution of Ramipril to a significant extent.

Keywords: Solubility analysis of cocrystals showed that Ramipril cocrystals have comparatively better solubility than the other cocrystals.


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