European Journal of Biomedical and Pharmaceutical Sciences

COMPARISON OF THE EFFICACY OF LEVETIRACETAM AND CLOBAZAM INDIVIDUALLY AND IN COMBINATION IN THE MANAGEMENT OF GENERALIZED TONIC-CLONIC SEIZURES IN A TERTIARY CARE HOSPITAL

Dr. Mohammed Ehteshaam Uz Zaman*, Dr. Afifa Fatima, Sumaiya Tabassum, Mohammed Safi Ur Rahman, Dr. Syed Jaffer, Dr. Uzma Samreen and Dr. BSV Raju

ABSTRACT

The aim of the study is to compare the efficacy of levetiracetam and clobazam individually and in combination in the management of generalised tonic-clonic seizures. An observational study was carried among patients admitted in the neurology department attending OPD of tertiary care hospital, Hyderabad. The study was carried out for a period of 6 months from September 2019 to February 2020. A total of 91 case sheets were analyzed during that period. A total of 91 case sheets were collected among which 54% were male and 46% were female. It was found that 10-20 years of age group made up the highest percentage of total population consisting upto 33% of the study population and the least populated group was 40-50 and 50-60 age group. Moreover, the results demonstrate that combination shows more efficacy than the individual drugs (levetiracetam and clobazam). This study clearly demonstrates that awareness of generalized tonic-clonic seizures in general the risk factors, signs and symptoms among hospitalized patients is inadequate. The findings of our study may also encourage health-care providers to deliver more education to patients and Patient Health Organizations about Generalized tonic-clonic seizures and their risk-factors, signs and symptoms and preventive measures.

Keywords: Tonic-clonic seizures, levetiracetam, clobazam, efficacy.