Abstract
DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR QUANTITATION OF BENDROFLUMETHAZIDE CONTENT USING UV-SPECTROSCOPIC TECHNIQUE

Rajesh S. Jadhav and Dr. Jagdish V. Bharad*

ABSTRACT

A Simple, easy, specific, speedy, precise and accurate UV Spectrophotometric technique have been developed and Validated for quantitation of Bendroflumethazide formulation drug. Bendroflumethazide showed the absorption maxima in at 273.0 nm and was linear for a range of 5 μg/ml–25 μg/ml with correlation coefficient of 0.9993. The validation of the above proposed method was done by carrying out precision and accuracy studies. The analytical method showed good Intra precision (Repeatability) with relative standard deviation 0.896% and Inter precision with relative standard deviation is 0.612% which is less than 2. The percentage recovery at three different levels i.e. 50%, 100% and 150% was found to be 49.3%, 100.0% and 149.2% respectively. The proposed analytical method was validated for the parameter Specificity, Precision, Linearity and range, Ruggedness, Accuracy and recovery. Hence proposed analytical method for quantitation of Bendroflumethazide formulation drug by UV spectrophotometer in pharmaceutical can be applied for the routine quality control analysis.

Keywords: Bendroflumethazide, UV Spectrophotometer, Validation.


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