Tolliboyeva Feruza To’lqin Qizi, Afzalova Sayyora Abduahadovna, Kukanova Nargiza Fahritdinovna, Pozilov Mamurjon Komiljonovich*, Abdulladjanova Nodira Gulomjanovna


In this study, the effect of gossitane and plantagin polyphenols on the respiration and oxidative phosphorylation processes of rat liver mitochondria under in vitro experimental conditions was studied. Rat liver mitochondria were isolated using differential centrifugation. The effect of polyphenol compounds on the respiratory rate and various metabolic processes of the liver mitochondria was determined by polyarography. The calculation of the respiration coefficient and ADP/O values was performed using the Chans method. Concentrations of 20, 40, and 60 μM were selected because the gossitan (C177H154O85) polyphenol was an individual compound selected for screening for the experiment. Since plantagin polyphenol compound consists of 4 composite compounds, their concentration was studied in μg / ml. Concentrations of plantagin 10 μg/ml, 20 μg/ml and 30 μg/ml were selected. Mitochondrial respiration accelerated as the concentration of gossitan in the incubation environment increased. While this was evident in case V3, no significant change was observed relative to control in case V4. Respiratory control and ADP/O value on mitochondrial Chans decreased at low concentrations of gossitan and plantagin, while at higher concentrations the respiratory coefficient and ADP/O index returned to control. With increasing concentrations of gossitan polyphenols in the incubation environment, mitochondrial respiration and oxidative phosphorylation began to have a positive effect on metabolic conditions. Plantagin polyphenol was found to increase liver mitochondrial respiration and oxidative phosphorylation processes relative to respiratory control and ADP/O performance.

Keywords: Liver, mitochondria, respiratory rate, oxidative phosphorylation, gossitan, plantagin.

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