Abstract
IMMUNOHISTOCHEMICAL STUDY OF TGF-?, PDL-1, AND IL-10 IN PATIENTS WITH TOXOPLASMAGONDII

H. A. Alsailawi*, S. S. Ayat, Mustafa Mudhafar, Ruaa K. Mohammed, Sahi J. Dhahi,
M. M. Abdulrasool, Shahad Shawkat and Hussein A. Raheem

ABSTRACT

The aim of this study to evaluate the expression of Programmed cell death-1 (PD-1), TGF- ß, and IL-10 in placental tissue of aborted women and the correlation with Toxoplasma.gondii (T. gondii) and the correlation of these cytokines with each other and with toxoplasmosis, during an abortion. The placental tissue samples have been processed and used for immunohistochemistry to study the expression of PDL-1, IL-10, and TGF-β. There was an increase in expression of TGF-β, PDL-1, and IL-10 in the placental tissue of aborted women infected with T.gondii,. The results of the study showed that the residence of pregnant women in an urban area or rural has no relation with Toxoplasmosis infection (P>0.05), Age shows a significant correlation with Toxoplasmosis, the risk of infection increased with age (P<0.05). The number of recurrent abortions has no significant correlation effect in toxoplasmosis infection and abortion between the positive and control groups (P>0.05), Placental expression of PDL-1, IL-10, and TGF-β show significant correlation during infection with toxoplasmosis (P<0.05).

Keywords: TGF-?, PDL-1, IL-10, Toxoplasmagondii.


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