Abstract
MEMBRANE ACTIVE PROPERTIES OF SOME ISOQUINOLINE ALKALOIDS

Muxamediyeva Irodaxon Baxtiyorxo`ja qizi, Rakhimalieva Shahzoda Rasuljon qizi, Pozilov Mamurjon Komiljonovich* and Sherzod Zhurakulov

ABSTRACT

In this study, 1- (4-dimethylaminophenyl) -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-24), 1- (2-chloro-4,5-methylenedioxyphenyl) -2-hydroxyethyl-6, the effect of 7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (N-14) isoquinoline alkaloids on calcium-induced mitochondrial swelling in rat heart mitochondria was studied in vitro. Mitochondrial edema was induced using the megachannel inducer CaCl2. The inhibitory effect of different concentrations of isoquinoline alkaloids on mitochondrial edema has been studied. The mPTP permeability of isoquinoline alkaloids has also been studied in comparative experiments with the classic inhibitor cyclophiline D. In experiments, the alkaloids F-24 and N-14 isoquinoline had an inhibitory effect on mitochondrial permeability in rat heart.

Keywords: Heart, Mitochondria, Swelling, Isoquinoline alkaloid N-14, F-24.


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