European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON NATURAL POLYMER USED IN ORAL DRUG DELIVERY MATRIX TABLET

Abhijeet Anand*, Vivek Kumar Patel, Prof. Rajeev Shukla and Dr. Abhishek Kumar

ABSTRACT

For sustained and controlled release of drugs matrix tablet is an most important tool. For administration of drugs oral route is most popular route. For sustained and controlled release of drugs tablets plays an important low cost approach. For water soluble and water insoluble drugs matrix tablets are mostly used for sustained release of drugs. Most widely used polymer in matrix tablet is hydrophilic polymer. In the preparation of matrix tablets, different types of polymers are used for controlling the release of drugs has develop most important tool. From matrix tablet drug release by both Dissolution controlled as well as diffusion controlled mechanism. Released of drugs from polymer matrices by complex interaction between swelling, Diffusion and erosion depending on the nature of the drug. In case of hydrophilic drugs, drug release is mediated mostly by diffusion mechanism.

Keywords: Matrix tablet, Natural polymer, Sustained release, oral route, Patient convenience and compliance.