European Journal of Biomedical and Pharmaceutical Sciences

SUSTAINED RELEASE DRUG DELIVERY SYSTEM: A REVIEW

Keerthana Devi* and Umar Faruk Sha

ABSTRACT

The terms Sustained-release, prolonged-release, modified release, extended-release, or depot formulations are accustomed to determine drug delivery systems that are designed to achieve or extend therapeutic effect by endlessly releasing medication over an extended amount of time when the administration of one dose. Presently pharmaceutical industries are specializing in the development of sustained-release formulations because of their inherent boons. Sustained continuously dose forms are designed to release a drug at a planned rate by maintaining a continuing drug level for a particular amount of your time with minimum aspect effects. The fundamental principle of a sustained-release drug delivery system optimizes the biopharmaceutical, pharmacokinetic, and, pharmacodynamics properties of a drug in such a way that its utility is maximized, side effects are reduced and cure of the sickness is achieved. There are many advantages of sustained-release (matrix) drug delivery over standard-dose forms like improved patient compliance because of less frequent drug administration, reduction of fluctuation in steady-state drug levels, most usage of the drug, inflated margin of safety of the potent drug, reduction in attention prices through improved medical care and shorter treatment amount. The fundamental goal of the sustained release is to give a promising way to decrease the aspect impact of the drug by preventing the fluctuation of the therapeutic concentration of the drug within the body and increasing patient compliance by reducing the frequency of dose.[1,2]

Keywords: Sustained-release, Matrix tablet, Patient compliance.