European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF CUBOSOMES LOADED EMULGEL OF OXICONAZOLE NITRATE

Joshah Varghese*, Sufairath and S. Mahendran

ABSTRACT

Dermatological conditions are known to be one of the most common medical conditions. Oxiconazole nitrate (OXN) is a potent anti-fungal drug which includes in azole derivatives (imidazole). But, Oxiconazole nitrate have poor solubility and comes under BCS class II. Also, it’s short half-life (3-5 h) and the side effects limits its application. Hence in this study, OXN was designed into the nano formulation called cubosomes to increase its solubility and incorporated into emulgel base to curtail the adverse effects of OXN by the transdermal route and to provide dual release system. Emulgel is evolving system for the topical drug delivery, where two systems have been incorporated i.e, Emulsion and the gel. Even though, gels show various advantages it still has constriction in the delivery of hydrophobic drugs. So, in order to overcome this problem, the concept for emulgel was introduced.

Keywords: Oxiconazole nitrate, cubosomes, Glyceryl monooleate, top-down approach, emulgel.