Abstract
PREVALENCE OF ANTIBACTERIAL RESISTANCE IN MICRO-ORGAMISMS AND THEIR ANTIBIOTIC PRESCRIBING PATTERN IN A TERTIARY CARE HOSPITAL SETTING

Sumaiya Tabassum*, Mohammed Safi ur Rahman, Uzma Samreen, Uma Sree Devi and BSV Raju

ABSTRACT

Our study aimed to observe the antimicrobial-resistant patterns in the Inpatient of a tertiary care hospital setting and to observe and evaluate the antibiotics therapy management. a retrospective observational study was carried out where the data of 261 patients were collected from a Microbiology lab and MRD. The duration of cases collected for the study was for 1 year 7 months. Accordingly, the most prevalent resistant microbe was Pseudomonas aeruginosa followed by E. coli and klebsiella. The type of infection which was most common among the sample considered was urinary tract infection. We found the empirical therapy prescribed was under WHO practice guidelines for antimicrobials. In 98 percent of patients, the empirical therapy was de-escalated and escalated which resulted in a decreased duration of treatment by short duration of prognosis of the treatment and decreased risk of secondary infections, and overall decreased economic cost of treatment. Gram-negative bacteria, such as E. coli, Pseudomonas aeruginosa and Klebsiella species, were common causes of infections, in our study the resistance pattern of these species to antibiotics such as cephalosporins, beta-lactams, or lactamases and fluoroquinolones was observed. Carbapenems have been considered the most effective treatment for the serious infections resulting from such resistant bacteria. Extended-spectrum beta lactamases markers were found in E. coli (n=41), K. pneumonia (n=45), and P. aeruginosa (n=51) clinical isolates. Co-resistance to various antibiotic classes was observed in ESBL producing isolates. All of the Extended-spectrum beta lactamases isolates were found to be sensitive to imipenem and Faropenem with a low proportion of resistance. The delivery of suitable antibiotics to patients can minimize the progression of the infection. Clinical studies are required to identify risk factors for multi-drug-resistant organisms’ development, as well as the economic impact of these infections, as well as the most effective antimicrobial therapies, and the duration of therapy to enhance outcomes in the treatment of multidrug-resistant infections.

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