Abstract
IMPORTANCE OF COMPUTED TOMOGRAPHY SCAN IN TRAUMATIC BRAIN INJURY DURING ROAD TRAFFIC ACCIDENT (RTA)

S. Kr Sah*, Liu Sibin, Lei Wei and Chen Lina

ABSTRACT

Background: Herbal medicines are widely used for the management of pain and inflammation. Most of the herbal formulations present in the market are not standardized with respect to its active ingredients marker molecule. Siddhayu Ayurvedic Research Foundation Pvt. Ltd. has developed and validated Painquit Tablet to be used for pain reliving, inflammation, mobility, flexibility and strength. Objective: The present study was designed with an objective of simultaneous estimation of 11-Keto-β-Boswellic acid and Withaferin A by HPTLC from Tablet containing Boswellia serrata and Withania somnifera. Methods: High performance Thin Layer Chromatography (HPTLC) method was developed and validated for simultaneous estimation of 11-Keto-β-Boswellic acid (KBA) and Withaferin A (WA) from Painquit Tablet. Chromatographic separation was achieved on precoated silica gel HPTLC aluminium plate 60 F254 using Chloroform: Ethyl Acetate: Formic acid, 7.0:3.0:1.0 (v/v/v) as mobile phase followed by densito-metric measurement at two different wavelength 258 nm and 227 nm by TLC Scanner 4 (CAMAG).The method was validated according to International Conference on Harmonization guidelines. Results: The retention factors of KBA acid and WA were 0.58 and 0.32 respectively. The estimated amount of KBA and WA was found to be 0.15 % and 0.09 %. Results obtained in validation parameters indicate the accuracy and reliability of the developed simultaneous HPTLC method for the quantification of KBA acid and WA in Painquit Tablet. Conclusion: The proposed method found to be simple, sensitive, selective and accurate for routinely used in Quality Control Lab. KEYWORDS: 11-Keto-β-Boswellic acid, Withaferin A, Painquit Tablet, HPTLC, pain reliving, inflammation. S. Kr Sah Department of Radiology, Central Hospital, Jingzhou, Hubei. Population and vehicle users are increasing day by day and RTA is also increasing day by day parallel way. Head trauma followed by brain injury is becoming the most common problem, especially in middle-aged people. It has taken second place next to cancer as a leading cause of death. Due to advance and developed radiology, computed tomography has become the prime choice in the initial assessment of head injury in patients as it is easily available, faster and highly accurate in detecting skull fractures of the skull and acute intracranial bleeding. Aim: To demonstrate the importance of Ct-scanning in the initial management planning, follow up and long term management of patients with traumatic head injury of varying severity in Patients. Methods: A prospective study has been carried out of 200 patients with road traffic accident with acute head trauma with positive CT scanning referred to central hospital, Jingzhou, Hubei, China between 2017 April to 2019 May (2-year prospective study). The affected age group was between (1-90) years and the great majority of them were males. Result: The affected age group was between (1-90) years and the great majority of them were males.77 % of all the 200 cases were males and 23% were females. Most of affected age group belongs to 61-70 years of age group. Their age ranged from 1 to 90 years, with a mean age of 51.88 years (±18.26) (mean±standard deviation). The median and modal age was 54 and 47 years, respectively. Most of the cases which were studied showed skull fractures, which indicates that there has been significant trauma and in a single case with more than one pathology, related to cranium has been seen. The most common post traumatic consequences found in the study of middle aged are subarachnoid hemorrhage, while other sequel such as contusion, subdural hematomas and extradural hematomas are encountered more. Diffuse and focal cerebral edema was being the most common pathology following trauma in children. Conclusion: CT scanning is the primary modality of choice in the diagnostic work up of patients with acute head trauma for identifying the various intracranial consequences following head injury especially within 48 hours which helps in the initial assessment, treatment planning, follow up and long term management of patients.

Keywords: Computed Tomography, Head Injury, Intracranial Hemorrhage, Fracture and Diagnosis.


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