Abstract
AN OBSERVATIONAL STUDY TO EVALUATE THE SAFETY, EFFICACY, AND QUALITY OF LIFE OF NEPA IN COMPARISON WITH ONDANSETRON IN MANAGEMENT OF CHEMOTHERAPY INDUCED NAUSEA AND VOMITING

S. Sai Bhavana*, Rathod Mahesh, Kaspa Nitheesh and Mohammed Ibrahim

ABSTRACT

Cancer is on the public health concerns among millions of people around the world and claims thousands of lives every year. The most fear-inducing side effects of chemotherapy are nausea and vomiting (CINV) which without appropriate antiemetic treatment may lead to experiencing these symptoms in 70%-80% of the cancer patients. Therefore, preventing and managing chemotherapy-induced nausea and vomiting is an important part of care planning for cancer patients. A prospective observational study was carried out to evaluate the safety, quality of life, and effectiveness of NEPA with Ondansetron in managing the patients with chemotherapy-induced nausea and vomiting. The FLIE questionnaire was provided to collect the responses from the patients and the data was given a scoring along with the CTCAE scale. The FLIE response shows that many patients didn’t experience nausea nor vomiting. The sample consists of 60 patients including both males and females age 18 years and above. Data was collected for a period of 6 months (September 2020- February 2021) from AOI Hospital, Lingampally and AIG Hospital, Gachibowli, Hyderabad. The results were documented and the data were analysed using SPSS software. Akynzeo showed better quality of life in patients compared to Ondansetron.

Keywords: CINV, NEPA, Ondansetron, FLIE (FUNCTIONAL LIVING INDEX EMESIS), CTCAE, SPSS software.


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