European Journal of Biomedical and Pharmaceutical Sciences

GASTRO PROTECTIVE ACTIVITY OF AQUEOUS ROOT EXTRACT OF TRAGIA INVOLUCRATA BY PYLORIC LIGATION METHOD

Divya C. V.*

ABSTRACT

In folk medicine, Tragia involucrata L (Euphorbiaceae) is used to treat stomach problems such as gastric ulcers and acidity. Gastric ulcer is one of the diseases that affect a huge population all over the world. Stress, smoking, dietary deficits, infections, and indiscriminate use of nonsteroidal anti-inflammatory medications are all etiological factors for this condition. The Tragia involucrta has been reported for the constituents including flavonoids, alkaloids, carbohydrates, 2-methylnanone, rutin, protein, vinyl hexylether, shellsol, tannins, sterols, saponins, 2,4-dimethyl hexane, and 2,6-dimethyl heptane ,stigmasterol, and quercetin. The goal of this study aimed for whether the aqueous extract of Tragia involucrata roots had any gastroprotective properties. The roots of tragia involucrata L. was made available from the rural market of Malabar, Kerala. The roots were dried, powdered and extracted with water to get aqueous extract of Tragia involucrata. Here induction of Gastric ulcer was experimentally produced by ligation of pylorus, and the aqueous extract of Tragia involucrata (AETI) roots was evaluated at doses of 200 and 400 mg/kg body weight orally. Gastric output volume, ulcer index , free acidity, total acidity, mucus content, pH and were used to evaluate anti-ulcer efficacy. The AETI was considerably reduced gastric ulceration at doses of 200 and 400 mg/kg.

Keywords: Tragia involucrata, Gastroprotective, anti-ulcer, Pyloric ligation.