Abstract
CLINICAL AND INVESTIGATIONAL PROFILE DIFFERENTIATING IMN FROM DIPHTHERIA

Dr. Sheela Mathew*, Dr. Aayilliath Kuttiyeri Adarsh and Dr. Aishwarya Ramesh

ABSTRACT

Back ground: Diphtheria is an ongoing epidemic in the state of Kerala in India since 2016. Disease is characterized by fever, odynophagia and membrane in throat with or without adenopathy. We had a group of young immunized patients admitted with membranous tonsillitis with unique investigational profile. Based on this presentation, PCR and antibody testing of Infectious mononucleosis (IMN) was done and found positive. Method: Data was collected from the records of patients admitted with a clinical diagnosis of diphtheria in infectious diseases ward of our institution. When the clinical, biochemical and hematological profiles were found different from diphtheria, EBV PCR and Ig M viral capsid antigen (VCA) were sent. Results: We had 18 patients with proved IMN. All had history of full dose childhood vaccination. All these patients were young, had regional adenopathy bilaterally, membrane in throat, tonsillar enlargement, elevated total count, Lymphocyte predominance, peripheral smear showing large numbers of atypical Lymphocytes, low CRP, normal or slightly elevated ESR and elevated liver enzymes. None had splenomegaly clinically and USG wise. All had EBV PCR and Ig M VCA positivity. All Diphtheria patients had very high ESR and CRP, polymorphonuclear leucocytosis and normal liver enzymes. Discussion: Youngsters with membranous tonsillitis with lymphocytosis, predominant atypical lymphocytes in peripheral smear, low CRP and altered LFT may be screened for EBV, thereby we can avoid administration of costly antitoxin, antibiotic and prolonged hospital stay. Also atypical lymphocytes in peripheral smear, low CRP and altered liver function abnormalities can be taken as surrogate markers for diagnosis of IMN without going for costly investigations.

Keywords: IMN, diphtheria, membranous tonsillitis.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2022 Issue has been successfully launched on 1 May 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT