Abstract
A STUDY OF THYROID-STIMULATING HORMONE, PROLACTIN, INSULIN RESISTANCE IN POLYCYSTIC OVARIAN SYNDROME AND THEIR CORRELATION WITH BODY MASS INDEX

Dr. Sannapa Ramaiah Meenakshi* and Dr. K. M. Umashankar

ABSTRACT

Background: Polycystic ovarian syndrome (PCOS) is a diverse and complicated female endocrine condition that affects one in every 15 women globally and is a substantial economic health burden that is expected to increase as obesity becomes more prevalent. Despite the fact that the pathogenesis of PCOS is not completely known, obesity and IR (Insulin Resistance) seem to have a critical part in the development of PCOS. Our study attempts to analyze the Thyroid-stimulating hormone (TSH), Prolactin (PRL), Fasting Insulin, and IR in the form of the HOMA-IR index and their correlation with BMI in PCOS controls. Materials and methods: A comparative cross-sectional research were carried out with 50 women having PCOS and 50 healthy women of similar age and BMI as controls. Fasting samples were examined for TSH, PRL, and Fasting Insulin levels by chemiluminescence immune assays and IR in the form of the HOMA-IR index. The results were then correlated with BMI. Statistical analysis was carried out using SAS 9.2, and SPSS 15.0 software. Results: A significant increase in PRL (22.49 ± 17.21 ng/ml vs 12.87±4.31ng/ml), Fasting insulin (13.51±6.12 vs 6.77±2.13μU/L), and HOMA-IR (2.76±1.21 vs 1.38±0.44), in PCOS patients in comparison to controls (P<0.001) was seen. Subclinical hypothyroidism, TSH >5 mIU/ml was observed in 22% of the PCOS patients. There was a strong relationship between HOMA-IR (P=0.001), and Fasting Insulin (P=0.004) with BMI in the PCOS group. Conclusion: The analysis revealed a higher incidence of mild hyerprolactinemia and mildly elevated TSH levels in PCOS. This implies the assessment of thyroid function and PRL levels in all PCOS patients. This work also showed increased Insulin Levels and marked IR in the PCOS group. Further IR showed a positive correlation to BMI indicating the need for lifestyle modification to improve fertility and prevent dysglycemic disease in the long run.

Keywords: Polycystic ovarian syndrome (PCOS), Prolactin (PRL), Body Mass Index (BMI), Insulin resistance (IR), Thyroid-stimulating hormone (TSH).


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: NOVEMBER ISSUE PUBLISHED

    NOVEMBER 2022 Issue has been successfully launched on 1 NOVEMBER 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT