European Journal of Biomedical and Pharmaceutical Sciences

BRUGADA SYNDROME: AN OVERVIEW

P. Malarvizhi Pharm D., Zum Zum S.*, Sharon Maria, M. Sivadharsha and Stefphy Mary Koshy

ABSTRACT

Brugada syndrome is an uncommon heart arrhythmic disease defined by sustained ST-segment elevation in the right pericardial leads and electrocardiographic right bundle branch block. It's linked to ventricular fibrillation and an increased risk of sudden cardiac death, especially in young men with structurally normal hearts. Patients with idiopathic ventricular fibrillation, self-terminating polymorphic ventricular tachycardia, a family history of sudden cardiac death in a child, and/or syncope with the distinctive electrocardiography (ECG) abnormalities should be suspected of the condition. Characterization of the RVOT's unique morphology and electrophysiology during the last few decades has shown the RVOT's arrhythmogenic characteristics. Despite recent insights from large population cohorts, risk classification among impacted patients remains a difficulty. The major therapy in Brugada syndrome is implantable cardiac defibrillators, which are linked with a high rate of problems. The key challenge is risk assessment of individuals with Brugada syndrome.

Keywords: Brugada syndrome, Arrhythmia, Genetic mutation, Defribrillator, Right ventricular outflow tract (rvot).