European Journal of Biomedical and Pharmaceutical Sciences

ROLE OF PROGESTERONE IN PREVENTING RECURRENT MISCARRIAGES IN PREGNANT WOMEN ATTENDING ANTENATAL UNIT OF SOUTH INDIAN HOSPITAL

Dr. Muzammil Fathima*, Dr.Fatima Hafeez, Dr. Fatima Tahniyath, Dr. Hasbeen Sultana, Dr. Mohammed Ashfaq Hussain, Dr. Roya Rozatti

ABSTRACT

Background: Progesterone plays an important role in regulating normal female reproductive functions. It is successful in preventing recurrent preterm delivery and unexplained miscarriages. Progesterone supplementation improves the pregnancy outcome in groups of recurrent miscarriages as progesterone is very important for embryonic survival, embryo development and implantation. Objective: To understand the role of progesterone in preventing recurrent miscarriages in pregnant women, to evaluate the outcome of Progesterone during pregnancy attending antenatal unit of south Indian hospital. Aim and Objective: To understand the role of progesterone in preventing recurrent miscarriages in pregnant women attending antenatal unit of south Indian hospital. Setting: Observational study was conducted over a period of 4 months from November 2013 to February 2014 in Antenatal Out Patient Department of Obstetrics and Gynaecology of Owaisi Hospital and Research Centre to evaluate the outcome of Progesterone during pregnancy and to study its role of preventing recurrent miscarriages. Method: Observational study was conducted over a period of 4 months from November 2013 to February 2014 in Antenatal Out Patient Department of Obstetrics and Gynaecology. Results:Out of 153 patients who agreed to give a written informed consent for the study, 11 patients preferred delivery outside our hospital. Average age of pregnant women was 30.6 ± 4.35 years (Range 15-40 years). Of 153 women 32 (20.9%) were of age group 15-20, 70(45.7%) women were between 21-25 being the highest, 39 (25.4%) women were between 26- 30, 11(7.1%) women of age 31-35 and only 1(0.6%) woman between age 36-40 years. The women grouped under Gravida (the number of pregnancies), 54(35.2%) of them in Primi gravida being the largest number, other pregnant women were found in Gravida I - 42(27.4%), Gravida II- 42(27.4%), Gravida III- 26(16.9%) Gravida IV- 21(13.7%) Gravida V- 05(3.2%) and 1(0.65%) pregnant woman in Gravida VI,VIII and X were given progesterone as a supportive treatment in order to give birth to a healthy and safe full term offspring . Conclusion: Progesterone treatment reduces the number of uterine contractions and significantly decreases pre term delivery rates. Progesterone supplementation was found to improve the pregnancy outcome in groups of recurrent miscarriages.

Keywords: Progesterone, Pregnancy, Recurrent miscarriages, Ante natal, OPD.